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Charlie Blackmon hit a lead-off homer and the Rockies went on to beat the Giants, 4-3.
Nolan Arenado smacked a two-run double during a three-run first for Colorado, which won a four-game series in San Francisco for the first time in franchise history.
Antonio Senzatela went seven innings to improve to 2-and-0. Greg Holland earned his seventh save.
Brandon Crawford laced an RBI triple as part of a three-run first for the Giants. Jeff Samardzija allowed all four runs during his seven-inning start to fall to 0-and-3.